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Histochemical studies on the effect of furapyrimidone on Litomosoides carinii in cotton rats

   
@article{APS4632,
	author = {Yuan-qing Yang and Hui-zhong Yang},
	title = {Histochemical studies on the effect of furapyrimidone on Litomosoides carinii in cotton rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {3},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Cotton rats infected with  were treated intragastrically with furapyrimidone 15 mg/kg/d×7 d. The histochemical changes of the worms were observed.
  The contents of glycogen, RNA, DNA, alkaline protein, protein-boundα-amino groups, protein-bound tyrosine, tryptophan, histidine, SH groups, phenol substance, the activities of ATPase and AKP in the filariae or microfilariae showed a decrease 3 d after the initiation of treatment. Some of them were markedly decreased or even disappeared 7 d after the initiation of treatment. On the contrary, the activity of ACP was higher than that in the control.
  There was no recovery even 7 d after the completion of the treatment.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4632}
}