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Effects of dauricine on physiologic properties of myocardium

  
@article{APS4626,
	author = {Gui-rong LI and Da-chao FANG and Chong-jia HU and Fu-hua LU},
	title = {Effects of dauricine on physiologic properties of myocardium},
	journal = {Acta Pharmacologica Sinica},
	volume = {5},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Dauricine(D), the alkaloid isolated from Menispermum dauricum DC, possesses anti-arrhythmic and hypotensive actions. Its effects upon the physiologic properties of myocardium were studied on cat papillary muscles. 20-30 minutes after dauricine 32 μM was added, the contractility was decreased to 72±(SD)6%, and the duration-intensity curve was shifted to the right (p<0.01) white the epinephrine concentration inducing automaticity was increased 4.6±3.1 times (p<0.01), and the functional refractory period (FRP) was prolonged from 315±13 ms to 362±44 ms p<0.02). The negative inotropism and automatism suggest that dauricine may be antagonistic to Ca++, while the decrease of excitability and the prolongation of FRP indicate that it may be due to its inhibition on Na+ current.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4626}
}