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Effects of tetrandrine on inotropic and toxic actions of cardiac glycosides and its relation to extracellular calcium

   
@article{APS4580,
	author = {Yi-yue Chen and Da-chao Fang and Fu-hua Lu},
	title = {Effects of tetrandrine on inotropic and toxic actions of cardiac glycosides and its relation to extracellular calcium},
	journal = {Acta Pharmacologica Sinica},
	volume = {3},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {The effects of tetrandrine (T) or Ca2+ on inotropic and toxic actions of 2 cardiac glycoside preparations, divasid and ouabain, were studied with isolated left atria of rabbits.
  Tetrandrine at a low but still hypotensive effective concentration (4.8μM) prolonged PET and reduced the toxicity of the 2 preparations. No effect on the degree of contraction amplitude increment was observed. These effects of tetrandrine are not attributable to its negative inotropic action. Since they were antagonized by Ca2+, it may be assumed that tetrandrine is a calcium antagonist.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4580}
}