@article{APS4577,
author = {Ying-qu Li and Dan-fan Yao and Sheng-liang Yu and Jian-xin Wang and Cun-ren Liu and Yu Cheng},
title = {Neural mechanism of bronchospasmolytic effect of sophocarpine hydrobromide},
journal = {Acta Pharmacologica Sinica},
volume = {3},
number = {3},
year = {2016},
keywords = {},
abstract = {In the isolated trachea of guinea pigs, sophocarpine relaxed the smooth muscles. This effect was blocked by a previous administration of propranolol. The perfusion of isolated guinea pig lungs showed that sophocarpine did not block the M-receptors of bronchial smooth muscle. It did not alter the level of true cholinesterase in blood. The peripheral anti-ACh effect of sophocarpine was not prominent.
With the modified air overflow method injections of sophocarpine 4 mg/kg into vertebral artery or 0.8 mg/kg into cisterna cerebello-medullaris of rabbits blocked the bronchoconstrictor effect of ACh. Its central bronchospasmolytic effect was blocked by a previous injection of propranolol into vertebral artery or cisterna cerebello-medullaris.
It is suggested that the action of sophocarpine is via the β-receptors in CNS.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4577}
}