@article{APS4559,
author = {Shu-hua Xiao and Cui-ying Wang and Pei-ying Jiao and Guo-zhong Chen and Yue-gui Yu and Xing-ju Yuan},
title = {Effect of praziquantel on ATP uptake and metabolism of Schistosoma japonicum},
journal = {Acta Pharmacologica Sinica},
volume = {3},
number = {2},
year = {2016},
keywords = {},
abstract = {When Schistosoma japonicum was exposed to culture medium containing [3H]ATP and praziquantel 0.1, 1 or 10μg/ml for 1—4 h, the [3H]ATP uptake decreased significantly in male worms, but not in females. If male schistosomes were exposed to praziquantel 1 or 10μg/ml for 1—4 h and then transferred to drug-free culture medium, the [3H]ATP uptake recovered to normal only in lower drug concentration group. The [3H]ATP uptake of male worms markedly decreased 1 h after intragastric gavage of praziquantel100 mg/kg to infected mice and recovered to normal 4 h later. However, [3H]ATP uptake of male worms was steadily inhibited 24 h after 300 mg/kg to infected mice. No effect on [3H]ATP uptake of female worms was seen.
Praziquantel promoted the transformation of [3H]ATP uptaken by male worms to [3H]AMP, while the incorporation of [3H]ATP to RNA of male worms was markedly inhibited. No apparent changes were observed in female worms.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4559}
}