%0 Journal Article
%T Bleomycin A derivative, 99mTc-BLAIDA: synthesis and distribution in tumor-bearing mice (author's transl)
%A Hu Yu–lin
%A Xie Yu-yuan
%A Tao Zheng-qin
%A Chen Zhen-jia
%A Zhang Jian-shi
%A Ding Guang-sheng
%A Ye De-hua
%A Wang Yun
%A Ma Ji-xiao
%J Acta Pharmacologica Sinica
%D 2016
%B 2016
%9 
%! Bleomycin A derivative, 99mTc-BLAIDA: synthesis and distribution in tumor-bearing mice (author's transl)
%K 
%X N-(4-bromoacetylaminoace-tanilido) iminodiacetic acid (AIDA) was synthesized by condensation of p-nitroaniline with nitrilotriacetic acid, catalytic reduction and subsequent acylation with bromoacetyl bromide. AIDA was conjugated with cobalt-bleomycin A5 to give BLAIDA, which was in turn labeled with 99mTc to yield 99mTc-BLAIDA.    99mTc-BLAIDA was tested on mice bearing sarcoma 180, brain tumor-22, murine hepatoma or Lewis lung carcinoma. The radioactivities in tumors were much higher than those in blood and other organs. The tumor/organ ratio was highest in case of sarcoma 180 at 12 h after iv 99mTc—BLAIDA. Hence 99mTc-BLAIDA is a potential tumor localizing agent for clinical diagnosis.
%U http://www.chinaphar.com/article/view/4556
%V 3
%N 2
%P 120-124
%@ 1745-7254