@article{APS4556,
author = {Yu–lin Hu and Yu-yuan Xie and Zheng-qin Tao and Zhen-jia Chen and Jian-shi Zhang and Guang-sheng Ding and De-hua Ye and Yun Wang and Ji-xiao Ma},
title = {Bleomycin A derivative, 99mTc-BLAIDA: synthesis and distribution in tumor-bearing mice (author's transl)},
journal = {Acta Pharmacologica Sinica},
volume = {3},
number = {2},
year = {2016},
keywords = {},
abstract = {N-(4-bromoacetylaminoace-tanilido) iminodiacetic acid (AIDA) was synthesized by condensation of p-nitroaniline with nitrilotriacetic acid, catalytic reduction and subsequent acylation with bromoacetyl bromide. AIDA was conjugated with cobalt-bleomycin A5 to give BLAIDA, which was in turn labeled with 99mTc to yield 99mTc-BLAIDA.
99mTc-BLAIDA was tested on mice bearing sarcoma 180, brain tumor-22, murine hepatoma or Lewis lung carcinoma. The radioactivities in tumors were much higher than those in blood and other organs. The tumor/organ ratio was highest in case of sarcoma 180 at 12 h after iv 99mTc—BLAIDA. Hence 99mTc-BLAIDA is a potential tumor localizing agent for clinical diagnosis.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4556}
}