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Topical delivery of silymarin constituents via the skin route

   
@article{APS4521,
	author = {Chi-feng Hung and Yin-ku Lin and Li-wen Zhang and Ching-hsien Chang and Jia-you Fang},
	title = {Topical delivery of silymarin constituents via the skin route},
	journal = {Acta Pharmacologica Sinica},
	volume = {31},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Aim: Silibinin (SB), silydianin (SD), and silychristin (SC) are components of silymarin. These compounds can be used to protect the skin from oxidative stress induced by ultraviolet (UV) irradiation and treat it. To this end, the absorption of silymarin constituents via the skin was examined in the present report.
Methods: Transport of SB, SD, and SC under the same thermodynamic activity through and into the skin and the effects of pH were studied in vitro using a Franz diffusion assembly.
Results: The lipophilicity increased in the order of SC},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4521}
}