@article{APS4498,
author = {Yi-chang Ni and Yue-qin Xu and Bao-ruo Shao},
title = {Mutagenicity of a new antimalarial drug, pyronaridine, in the Salmonella/microsome system},
journal = {Acta Pharmacologica Sinica},
volume = {3},
number = {1},
year = {2016},
keywords = {},
abstract = {The mutagenic activity of a new antimalarial drug, pyronaridine, was studied on 5 histidine-requiring strains of Salmonella typhimurium (TA100, TA98, TA1535, TA1537 and TA1538) with and without S-9, using the plate test.
After the rats had been induced by PCB, S-9 were isolated from the livers. Two antiparasitic drugs with known mutagenicity, hycanthone and furapromide, were used as positive controls.
In strain TA1537, pyronaridine induced mutations without S-9 at the doses of 100-1000 μg/plate. The His+ revertants per plate increased dose-dependently. Pyronaridine did not induce mutations of other 4 strains.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4498}
}