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Insulin induced translocation of Na+/K+-ATPase is decreased in the heart of streptozotocin diabetic rats

   
@article{APS4451,
	author = {Klara Rosta and Eszter Tulassay and Anna Enzsoly and Katalin Ronai and Ambrus Szantho and Tamas Pandics and Andrea Fekete and Peter Mandl and Agota Ver},
	title = {Insulin induced translocation of Na+/K+-ATPase is decreased in the heart of streptozotocin diabetic rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {30},
	number = {12},
	year = {2016},
	keywords = {},
	abstract = {Aim: To investigate the effect of acute insulin administration on the subcellular localization of Na+/K+-ATPase isoforms in cardiac muscle of healthy and streptozotocin-induced diabetic rats.
Methods: Membrane fractions were isolated with subcellular fractionation and with cell surface biotinylation technique. Na+/K+-ATPase subunit isoforms were analysed with ouabain binding assay and Western blotting. Enzyme activity was measured using 3-O-methylfluorescein-phosphatase activity.
Results: In control rat heart muscle α1 isoform of Na+/K+ ATPase resides mainly in the plasma membrane fraction, while α2 isoform in the intracellular membrane pool. Diabetes decreased the abundance of α1 isoform (25 %, P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4451}
}