@article{APS4430,
author = {Ying Xiao and Xiang Xue and Yuan-feng Wu and Guo-zheng Xin and Yong Qian and Tian-pei Xie and Li-kun Gong and Jin Ren},
title = {β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism},
journal = {Acta Pharmacologica Sinica},
volume = {30},
number = {11},
year = {2016},
keywords = {},
abstract = {Aim: The role of CYP1A in the protection of aristolochic acid (AA)I-induced nephrotoxicity has been suggested. In the present study we investigated the effects of β-naphthoflavone (BNF), a non-carcinogen CYP1A inducer, on AAI-induced kidney injury.
Methods: Mice were pretreated with 80 mg/kg BNF by daily intraperitoneal injection (ip) for 3 days followed by a single ip of 10 mg/kg AAI. AAI and its major metabolites in blood, liver and kidney, the expression of CYP1A1 and CYP1A2 in microsomes of liver and kidney, as well as the nephrotoxicity were evaluated.
Results: BNF pretreatment prevented AAI-induced renal damage by facilitating the disposal of AAI in liver. BNF pretreatment induced the expression of CYP1A1 in both liver and kidney; but the induction of CYP1A2 was only observed in liver.
Conclusion: BNF prevents AAI-induced kidney toxicity primarily through CYP1A induction.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4430}
}