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Inhibition of tubulointerstitial fibrosis by pentoxifylline is associated with improvement of vascular endothelial growth factor expression

   
@article{APS4412,
	author = {Qiu-gen Zhou and Fa-lei Zheng and Fan-fan Hou},
	title = {Inhibition of tubulointerstitial fibrosis by pentoxifylline is associated with improvement of vascular endothelial growth factor expression},
	journal = {Acta Pharmacologica Sinica},
	volume = {30},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Aim: Recent information indicates that pentoxifylline (PTX) has the ability to suppress inflammation and profibrotic cell proliferation. In this study, we investigated the effect of PTX on tubulointerstitial fibrosis and the expression of vascular endothelial growth factor (VEGF) in a rat model of obstructive nephropathy.
Methods: Wistar rats with left ureteral ligation were divided into control and PTX-treated groups. The histopathologic degree of tubulointerstitial fibrosis was scored with PAS and Masson-stained sections. The protein and mRNA for vascular endothelial growth factor (VEGF) were semiquantitatively measured with immunohistochemistry and RT-PCR. The protein for transforming growth factor β1 (TGFβ1) and hypoxia-induced factor 1 alpha (HIF-1α) was determined by Western blot.
Results: Compared with the control group, PTX treatment reduced fibrosis scores at d 7 and d 14 (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4412}
}