@article{APS4397,
author = {Xin-wen Dong and Zhi-hua Jiang and E Shen},
title = {Effects of intracerebral injection of 6-hydroxydopamine in nucleus raphe magnus on electro-puncture analgesia in rats},
journal = {Acta Pharmacologica Sinica},
volume = {3},
number = {1},
year = {2016},
keywords = {},
abstract = {The effects of injection of 6-OH-DA into the nucleus raphe magnus were studied with both behavioral and fluorescence histocliernical methods in rats. Eight rats were injected intracerebrally 6-OH-DA and 9 rats received a vehicle. Pain threshold was measured by tail-flick and vocalization following electric stimulation of the tail. The electropuncture analgesic effect was enhanced 3 d later. The fluorescence of NA terminals in the nucleus raphe magnus disappeard almost completely, while the 5-HT-containing neurons in the nucleus remained undamaged. The control rats showed no changes in electropuncture analgesia nor in histo-fluorescence findings. The results provide an evidence for the antagonism between NA and 5-HT in the nucleus raphe magnus in modulation of pain.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4397}
}