@article{APS4382,
author = {Jian-guang Yu and En-hui Zhang and Ai-jun Liu and Jian-guo Liu and Guo-jun Cai and Ding-feng Su},
title = {Ketanserin improves cardiac performance after myocardial infarction in spontaneously hypertensive rats partially through restoration of baroreflex function},
journal = {Acta Pharmacologica Sinica},
volume = {34},
number = {12},
year = {2016},
keywords = {},
abstract = {Aim: Baroreflex dysfunction is associated with a higher rate of sudden death after myocardial infarction (MI). Ketanserin enhances baroreflex function in rats. The present work was designed to examine whether ketanserin improves the post-MI cardiac function and to explore the possible mechanism involved.
Methods: Spontaneously hypertensive rats (SHR) were treated with ketanserin (0.3 mg·kg−1·d−1). Two weeks later, blood pressure and baroreflex function were measured, followed by a ligation of the left coronary artery. The expressions of vesicular acetylcholine transporter (VAChT) and α7 nicotinic acetylcholine receptor (α7-nAChR) in ischemic myocardium, angiogenesis, cardiac function, and left ventricular (LV) remodeling were evaluated subsequently.
Results: Ketanserin significantly improved baroreflex sensitivity (0.62±0.21 vs 0.34±0.12 ms/mmHg, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4382}
}