TY  - JOUR
AU  - Wu Lin-lin
AU  - Yang Xin-bo
AU  - Huang Zheng-ming
AU  - Liu He-zhi
AU  - Wu Guang-xia
PY  - 2016
TI  - In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik
JF  - Acta Pharmacologica Sinica; Vol 28, No 3 (March 2007): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - Aim:  To assess the anti-hepatitis B virus (HBV) effect of hyperoside extracted from Abelmoschus manihot(L) medik. Methods:  The human hepatoma Hep G2.2.15 cell culture system and duck hepatitis B virus (DHBV) infection model were used as in vivo  and in vitro models to evaluate the anti-HBV effects. Results:  In the cell model, the 50% toxic concentration of hyperoside was 0.115 g/L; the maximum nontoxic concentration was 0.05 g/L. On the maximum nontoxic concentrations, the inhibition rates of hyperoside on HBeAg and HBsAg in the 2.2.15 cells were 86.41% and 82.27% on d 8, respectively. In the DHBV infection model, the DHBV-DNA levels decreased significantly in the treatment of 0.05 g- kg－1·d－1 and 0.10 g·kg－1·d－1 dosage groups of hyperoside (P
UR  - http://www.chinaphar.com/article/view/4371