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In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik

   
@article{APS4371,
	author = {Lin-lin Wu and Xin-bo Yang and Zheng-ming Huang and He-zhi Liu and Guang-xia Wu},
	title = {In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik},
	journal = {Acta Pharmacologica Sinica},
	volume = {28},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Aim:  To assess the anti-hepatitis B virus (HBV) effect of hyperoside extracted from Abelmoschus manihot(L) medik. Methods:  The human hepatoma Hep G2.2.15 cell culture system and duck hepatitis B virus (DHBV) infection model were used as in vivo  and in vitro models to evaluate the anti-HBV effects. Results:  In the cell model, the 50% toxic concentration of hyperoside was 0.115 g/L; the maximum nontoxic concentration was 0.05 g/L. On the maximum nontoxic concentrations, the inhibition rates of hyperoside on HBeAg and HBsAg in the 2.2.15 cells were 86.41% and 82.27% on d 8, respectively. In the DHBV infection model, the DHBV-DNA levels decreased significantly in the treatment of 0.05 g- kg－1·d－1 and 0.10 g·kg－1·d－1 dosage groups of hyperoside (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4371}
}