@article{APS4357,
author = {Yi-fan Zhang and Xiao-yan Chen and Xiao-jian Dai and Yi-ni Zhang and Qi-zhi Liu and Hua-ling Yu and Da-fang Zhong},
title = {Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients},
journal = {Acta Pharmacologica Sinica},
volume = {28},
number = {8},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the influence of omeprazole on the pharmacokinetics of domperidone given as free base and maleate salt.
Methods: An open, randomized, 2-period crossover study with a washout period of 7 d was conducted in 10 healthy Chinese, male patients. In each study period, the patients were administered a single oral dose of 10 mg domperidone as free base or maleate salt on d 1, 20 mg omeprazole twice daily on d 2 and 3, and once on d 4. A single dose of 10 mg domperidone as free base or maleate salt was taken at 4 h after administration of omeprazole on d 4. Plasma samples were collected on d 1 and 4 after the administration of domperidone, and the plasma concentrations of domperidone were determined by a sensitive liquid chromatography-tandem mass spectrometry method.
Results: For free-base domperidone, pretreatment with omeprazole resulted in a 16% decrease in maximum concentration (Cmax), compared with administration alone (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4357}
}