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Morphine enhances purine nucleotide catabolism in vivo and in vitro

   
@article{APS4326,
	author = {Chang Liu and Jian-kai Liu and Mu-jie Kan and Lin Gao and Hai-ying Fu and Hang Zhou and Min Hong},
	title = {Morphine enhances purine nucleotide catabolism in vivo and in vitro},
	journal = {Acta Pharmacologica Sinica},
	volume = {28},
	number = {8},
	year = {2016},
	keywords = {},
	abstract = {Aim: To investigate the effect and mechanism of morphine on purine nucleotide catabolism.
Methods: The rat model of morphine dependence and withdrawal and rat C6 glioma cells in culture were used. Concentrations of uric acid in the plasma were measured by the uricase-rap method, adenosine deaminase (ADA) and xanthine oxidase (XO) in the plasma and tissues were measured by the ADA and XO test kit. RT-PCR and RT-PCR-Southern blotting were used to examine the relative amount of ADA and XO gene transcripts in tissues and C6 cells.
Results: (i) the concentration of plasma uric acid in the morphine-administered group was significantly higher (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4326}
}