@article{APS4273,
author = {Yuan-qing Yang and Hui-zhong Yang and Yu-xin Xu and Yu-rui Xi},
title = {Histological changes of litomosoids carinii in cotton rats treated with furapyrimidone},
journal = {Acta Pharmacologica Sinica},
volume = {2},
number = {4},
year = {2016},
keywords = {},
abstract = {Cotton rats infected with Litomosoides carinii were treated intragastrically with furapyrimidone 15 mg/kg daily for 7 days. Some of the adult filariae were encapsulated by dense fibrinous membrane 1-3 days after the completion of treatment. The dead worm nodules were found on day 7 and some of them were found adhering firmly to the pleural wall on day 23 after the completion of treatment. Edema of the body cavity, degeneration of ovary, and deformation and degeneration of the ovary, and deformation and degeneration of the ova, embryos and microfilariae in the uteri of female worms were seen as early as on day 4 after the initiation of treatment. A great many dead worm abscesses or granulomas formed on day 3 in females and on day 7 in males after the completion of treatment. Many dead microfilariae in the inflammatory exudates of pleural cavities of rats were found on d 1-3 after the completion of treatment.
The results indicate that the furapyrimidone is the drug of choice to kill both the filariae and microfilariae.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4273}
}