@article{APS4248,
author = {Xiao-bin Bi and Yu-bin Deng and Dan-hui Gan and Ya-zhu Wang},
title = {Salvianolic acid B promotes survival of transplanted mesenchymal stem cells in spinal cord-injured rats},
journal = {Acta Pharmacologica Sinica},
volume = {29},
number = {2},
year = {2016},
keywords = {},
abstract = {Aim: Stem cells hold great promise for brain and spinal cord injuries (SCI), but cell survival following transplantation to adult central nervous system has been poor. Salvianolic acid B (Sal B) has been shown to improve functional recovery in braininjured rats. The present study was designed to determine whether Sal B could improve transplanted mesenchymal stem cell (MSC) survival in SCI rats.
Methods: SCI rats were treated with Sal B. The Basso–Beatie–Bresnahan (BBB) scale was used to test the functional recovery. Sal B was used to protect MSC from being damaged by TNF-α in vitro. Bromodeoxyuridine-labeled MSC were transplanted into SCI rats with Sal B intraperitoneal injection, simul-taneously. MSC were examined, and the functional recovery of the SCI rats was tested.
Results: Sal B treatment significantly reduced the lesion area from 0.26±0.05 mm2 to 0.15±0.03 mm2 (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4248}
}