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Effect of praziquantel on glycogen content and [1-14C]glucose uptake in Schistosoma japonicum

  
@article{APS4190,
	author = {Shu-hua Xiao and Cui-ying Wang and Pei-ying Jiao and Yue-gui Yu and Xing-ju Yuan},
	title = {Effect of praziquantel on glycogen content and [1-14C]glucose uptake in Schistosoma japonicum},
	journal = {Acta Pharmacologica Sinica},
	volume = {2},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {When pairs of Schistosoma japonicum were exposed to culture medium containing praziquantel 1 or 10 microg/ml for 4 h, the glycogen content, [1-14C]glucose uptake, and incorporation of [1-14C]glucose into the glycogen were markedly decreased. Male schistosomes seemed to be more affected.
After bisexual worms had been maintained in praziquantel 1 and 10 microg/ml for 4 h, and then transferred to drug-free culture medium for 4-18 h, the glycogen content and [1-14C]glucose uptake of female worms recovered promptly. In male worms the changes caused by praziquantel 1 microg/ml were reversible, while those caused by 10 microg/ml were not. 
Infected mice were given intragastrically praziquantel 20 mg/kg. After 2-4 h the glycogen content of the bisexual worms decreased markedly, but recovered in 48 h. After ig 100-300 mg/kg, no apparent recovery of glycogen content was seen 72 h later. When the worms perfused out from the mice 8 h after ig 100-300 mg/kg were maintained in vitro, the glycogen conent, [1-14C]glucose uptake and incorporation of [1-14C]glucose into the glycogen of the female worms could recover, but the recovery was not significantly in male worms.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4190}
}