@article{APS4182,
author = {Jiang-tao Yan and Lan Zhang and Yu-jun Xu and Xiao-jing Wang and Cong-yi Wang and Dao-wen Wang},
title = {Polymorphisms of genes in nitric oxide-forming pathway associated with ischemic stroke in Chinese Han population},
journal = {Acta Pharmacologica Sinica},
volume = {32},
number = {11},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the association of polymorphisms in four critical genes implicated in the NO-forming pathway with ischemic stroke (IS) in a Chinese Han population.
Methods: DNA samples of 558 IS patients and 557 healthy controls from Chinese Han population were genotyped using the TaqmanTM 7900HT Sequence Detection System. Six SNPs (rs841, rs1049255, rs2297518, rs1799983, rs2020744, rs4673) of the 4 related genes (eNOS, iNOS, GCH1, and CYBA) in the NO forming pathway were analyzed using the SPSS 13.0 software package for Windows.
Results: One SNP located in the intron of GCH1 (rs841) was associated with IS independent of the traditional cardiovascular risk factors in co-dominant and dominant models (P=0.003, q=0.027; P=0.00006, q=0.0108; respectively). Moreover, the combination of rs1049255 CC+CT and rs841 GA+AA genotypes was associated with significantly higher risk for IS after adjustments (OR=1.73, 95% CI: 1.27–2.35, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4182}
}