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A method of constant-rate perfusion for studying the renal vascular resistance of rats

  
@article{APS4172,
	author = {Xian-liang Tang and Xiu Chen},
	title = {A method of constant-rate perfusion for studying the renal vascular resistance of rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {2},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {The renal vascular resistances of rats were measured on the constant-rate perfusion preparations. By catherizing the abdominal aorta above and below the origin of the renal artery, the extracorporeal circulation of kidneys was driven by a constant-speed pump. The blood pressure distal to the pump was taken as a measure of local vascular resistance. After ligation of superior mesenteric artery, the results represented solely the vascular resistance of the renal arteries. Drug could also be administered intra-arterially by injecting them into the perfusing system in order to expose any direct action.
The validity of the method was examined by clonidine, N-methyltyramine and dopamine. The hemodynamic changes in rats matched to those in dogs.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4172}
}