@article{APS4170,
author = {Zi-en Cao and Jian-fan Shen and Jia-zhen Song and Zhen-ming Hu and Xing-zhong Zhu},
title = {Hypotensive action of cycleanine dimethobromide},
journal = {Acta Pharmacologica Sinica},
volume = {2},
number = {3},
year = {2016},
keywords = {},
abstract = {The nervi splanchnici major of 10 dogs were cut and the distal ends were stimulated. The hypertensive effect was markedly diminished or abolished after iv cycleanine dimethobromide 1-2 mg/kg. The hypotensive effects from the electrical stimulation at the distal ends of left vagi in 3 bilaterally vagotomized dogs was greatly diminished or abolished after iv 2-3 mg/kg.
The histamine levels in arterial blood of 9 dogs rose from 19+/-(SD) 6 ng/ml to 227+/-203 ng/ml after iv 1 mg/kg.
Twelve rabbits were given iv the drug and monitored by ECG. In 2 rabbits SAB II* developed after 1 mg/kg (in 3 s), AVB III* and ventricular escape appeared in one and auricular extrasystole in the other rabbit. In 10 rabbits given 0.75 mg/kg in 3 s, only the sinus rates showed some diminution. Five minutes later an additional dose of 0.75 mg/kg was given iv in 3 s in 6 out of the 10 rabbits. All these 6 rabbits manifested SAB II*, while 1 rabbit showed AVB I* and ventricular escape, and another rabbit developed ventricular extrasystole. In 2 rabbits the additional doses were 1.25 and 1.50 mg/kg, respectively and iv slowly in 20 min. The sinus rates decreased progressively.
The contraction amplitudes of 7 isolated rabbit hearts were not augmented or even diminished by cycleanine dimethobromide 200 mg/L.
So the ganglionic blocking effect plays an important role in the mechanism of the hypotensive action.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4170}
}