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Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro

   
@article{APS4139,
	author = {Qi Ye and Qiao-yan Zhang and Cheng-jian Zheng and Yang Wang and Lu-ping Qin},
	title = {Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro},
	journal = {Acta Pharmacologica Sinica},
	volume = {31},
	number = {12},
	year = {2016},
	keywords = {},
	abstract = {Aim: To investigate the anti-hyperprolactinemia activity of casticin, a flavonoid isolated from Vitex rotundifolia, and elucidate its molecular mechanism.
Methods: Hyperprolactinemia (MIHP) was induced by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d) in SD rats and the primary pituitary cells were prepared from the pituitary glands of the SD rats. Prolactin concentrations were measured using a radioimmunoassay. Cell viability was measured using an MTT assay. The mRNA expression of estrogen receptor alpha and beta in rat pituitary cells was measured using semi-quantitative RT-PCR analysis.
Results: The level of serum prolactin in the MIHP model group was 2.1 fold higher than that in the untreated control group (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4139}
}