@article{APS4136,
author = {Hong Wang and Bin Yang and Guang-wei Han and Shi-tong Li},
title = {Potency of nondepolarizing muscle relaxants on muscle-type acetylcholine receptors in denervated mouse skeletal muscle},
journal = {Acta Pharmacologica Sinica},
volume = {31},
number = {12},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the changing resistance to nondepolarizing muscle relaxants (NDMRs) during the first month after denervation.
Methods: The denervated and innervated skeletal muscle cells were examined on days 1, 4, 7, 14, 21, and 28 after denervation. Individual denervated and innervated cells were prepared from the flexor digitorum brevis of the surgically denervated and contralateral hind feet, respectively. Nicotinic acetylcholine receptors (nAChRs) in the cells were activated with 30 μmol/L acetylcholine, either alone or in combination with various concentrations of vecuronium. Currents were recorded using a whole-cell patch-clamp technique.
Results: The concentrations of vecuronium resulting in half-maximal inhibitory responses (IC50) increased 1.2- (P>0.05), 1.7-, 3.7-, 2.5-, 1.9-, and 1.8-fold (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/4136}
}