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Some toxicities of triptolide in mice and dogs

  
@article{APS4115,
	author = {You-lan Cheng and Ju-rong Ye and Da-jie Lin and Lu-jie Lin and Jun-ning Zhu},
	title = {Some toxicities of triptolide in mice and dogs},
	journal = {Acta Pharmacologica Sinica},
	volume = {2},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Triptolide is one of the antileukemic principles isolated from Trypterygium wilfordii. The acute LD50 of triptolide in mice=0.8 mg/kg iv and 0.9 mg/kg ip.
Twelve dogs were given in 20, 40, 80 or 160 microg/kg daily for 7 days. The major target organs of toxicity were heart, liver and gitract. The lethal dose (160 microg/kg) depressed the hematopoietic system of bone marrow. Toxic doses low and toxic doses high were found to be 40 an 80 mirog/kg, respectively. The toxicities on heart, hematopoietic system and gi tract were reversible. No toxicity was found after 20 microg/kg. Delayed toxicity was absent in 6 weeks after withdrawal of triptolide.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4115}
}