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Effect of acetaminophen (paracetamol) on human osteosarcoma cell line MG63

   
@article{APS4106,
	author = {Lourdes Díaz-Rodríguez and Olga García-Martínez and Manuel Arroyo-Morales and Belén Rubio-Ruiz and Concepción Ruiz},
	title = {Effect of acetaminophen (paracetamol) on human osteosarcoma cell line MG63},
	journal = {Acta Pharmacologica Sinica},
	volume = {31},
	number = {11},
	year = {2016},
	keywords = {},
	abstract = {Aim: To examine the effects of acetaminophen (paracetamol), a nonsteroidal anti-inflammatory drug (NSAID), on different cellular and functional parameters of the human osteosarcoma cell line MG63.
Methods: Flow cytometry was used to study proliferation, antigenic profile, and phagocytic activity, and radioimmunoassay was used to determine osteocalcin synthesis as a cell differentiation marker.
Results: Short-term treatment with therapeutic doses of paracetamol(5 or 25 μmol/L) reduced cell proliferation, osteocalcin synthesis, and phagocyte activity, and increased the expression of antigens involved in antigen presentation to T lymphocytes (CD80, CD86, HLA-DR).
Conclusion: These findings suggest that paracetamol activates the osteoblast, inducing its immunogenic action to the detriment of its bone formation capacity.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4106}
}