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Relationship between the central alpha-adrenoceptors and central effects of morphine

   
@article{APS4066,
	author = {Shao-xuan Fu and Shi-shan Zhang and Yuan Jin and Yun-shan Li},
	title = {Relationship between the central alpha-adrenoceptors and central effects of morphine},
	journal = {Acta Pharmacologica Sinica},
	volume = {1},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {In conscious rats, noradrenaline given intracerebroventricularly(icv) exhibited marked antidiuretic effect and antagonized the antidiuretic effect of morphine administered subcutaneously(sc). Although icv clonidine had no apparent-effect on the urine volume, it antagonized the antidiuretic effect of morphine. Both phentolamine and phenoxybenzamine given icv showed antidiuretic effect and enhanced the morphine-induced antidiuretic action.Phenoxybenzamine,yohimbine or phentolamine given by icv route showed antinociceptive effect in mice using the hot-plate method. The sc ED50 for morphine analgesia was significantly reduced when icv ED20 analgesic doses of phenoxybenzamine. These results suggested that the functional state of central alpha-adrenoceptors could modify the central effects of morphine, and that the morphine analgesia was more closely related with the attenuation of central adrenoceptor activity in the post-synaptic alpha-adrenoceptive sites.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4066}
}