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Antimalarial activities of 25 derivatives of artemisinine against chloroquine-resistant plasmodium berghei

   
@article{APS4062,
	author = {Hao-ming Gu and Bao-feng Lv and Zhi-xiang Qu},
	title = {Antimalarial activities of 25 derivatives of artemisinine against chloroquine-resistant plasmodium berghei},
	journal = {Acta Pharmacologica Sinica},
	volume = {1},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {The antimalarial activities of 25 derivatives of artemisinine, including dihydroartemisinine, 13 ethers, 6 esters and 5 carbonates, were compared. Each compound, dissovlved in tea seed oil, was injected intramuscularly into mice infected with the chloroquine-resistant strain of Plasmodium berghei. Adopting SD90 as a comparision criterion, the results showed that many of the derivatives were much more potent than artemisinine. They are SM224(O-methyl dihydroartemisinine, beta) in the ethers, SM241 (butyryl dihydroartmisinine, alpha) and SM108 ( propionyl dihydroartmisinine, alpha) in the esters, and SM242(propoxy carbonyl dihydroartmisinine, alpha), SM275( ethoxy carbonyl dihydroartmisinine, alpha+beta), SM223 (ethoxy carbonyl dihydroartmisinine, alpha ) and SM 276 ( phenoxy carbonyl dihydroartmisinine, alpha+beta) in the carbonates. Their chemical structures and values of SD90 are presented in Table 1.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4062}
}