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All- trans retinoic acid inhibited angiotensin II-induced increase in cell growth and collagen secretion of neonatal cardiac fibroblasts

   
@article{APS4046,
	author = {Yan He and Ying Huang and Li Zhou and Li-min Lu and Yi-chun Zhu and Tai Yao},
	title = {All- trans  retinoic acid inhibited angiotensin II-induced increase in cell growth and collagen secretion of neonatal cardiac fibroblasts},
	journal = {Acta Pharmacologica Sinica},
	volume = {27},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Aim:  To determine whether all-trans retinoic acid (at RA) acts to modulate angiotensin II (Ang II)-induced cardiac fibroblast cell growth and collagen secretion. Methods:  Cultured neonatal rat cardiac fibroblasts (CF) were used in the experiment. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to detect cell growth of the CF; and immunocytochemistry and Western blotting were used to measure the production and secretion of collagen and the expression of transforming growth factor-β1 (TGF-β1) by the CF. Results:  at RA (1×10-7 to 1×10-5 mol/L) inhibited the Ang II-induced increase in cell growth of CF (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/4046}
}