@article{APS3988,
author = {Xi-can Tang and Jie Feng and Yue-e Wang and Ming-zhang Liu},
title = {Neuromuscular blocking activity of alkaloids of Cyclea hainanensis},
journal = {Acta Pharmacologica Sinica},
volume = {1},
number = {1},
year = {2016},
keywords = {},
abstract = {The neuromuscular blocking activity of 4’’-o-methyl-d-curine and dl-curine isolated from Cyclea hainanensis in Hai-nan Island were studied. It was found that the dimethyl dl-curine dimethochloride was 1-2.5 times more active than d-tubocurarine in conscious rabbits,cats and dogs,while 4’’-o-methyl-d-curine dimethiodide was less potent than d-tubocurarine.Dimethyl dl-curine dimethochloride. Dimethyl dl-curine dimethochloride and 4’’-o-methyl-d-curine dimethiodide had a non-depolarizing mode of action.In contrast to d-tubocurarine,its ganglion-blocking potency and histamine-releasing properties were weak. Hence the side effect of hypotension seen with d-tubocurarine was less severe than that with dimethyl dl-curine dimethochloride and 4’’-o-methyl-d-curine dimethiodide. In mice and rats dimethyl dl-curine dimethochloride and 4’’-o-methyl-d-curine dimethiodide exhibited a higher therapeutic index than d-tubocurarine.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3988}
}