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l-Tetrahydropalmatine (l-THP) is a drug for assuaging dull pain and anxiety insomnia.

   
@article{APS3987,
	author = {Guo-zhang Jin and Xue-jun Liu and Lei-ping Yu and Jian Xu},
	title = {l-Tetrahydropalmatine (l-THP) is a drug for assuaging dull pain and anxiety insomnia.},
	journal = {Acta Pharmacologica Sinica},
	volume = {1},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {In this paper, a study on the catalepsy was made on rats. 1 . Given intraperitoneally 70~100 mg/kg in rats, l-THP caused not only a catalepsy, but also a significant rise of 5-HIAA in the brain, which is a valid index of serotoninergic neuronal activities.  2. If the activities of 5-HT neurons were depressed by PCA (20 mg/kg, ip) or PCPA ( 300 mg/kg, ip) 48 hours previously, l-THP produced in rats a marked augmentation of catalepsy associated with a significant decrease of 5-HT and 5-HIAA contents in brain. This augmentation lasted more than 7 hours. Cinanserin, a blocking anent of 5-HT receptor, also exhibited a similar but less augmentation.  3. If the activities of 5-HT neurons were strengthened by an injection of a load-dosage of l-tryptophan or probenecid, the catalepsy induced by l-THP was reduced.  These results showed that the brain serotoninergic system was involved in l-THP-induced catalepsy, which bore an inverse relationship to the content of brain serotonin.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/3987}
}