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Binding of 8 glycolate esters with muscarinic cholinergic receptor in mouse brain

   
@article{APS3984,
	author = {Heng Xu and Wen-qiao Jin and Xing-lin Xia and Zhi-qiang Chi},
	title = {Binding of 8 glycolate esters with muscarinic cholinergic receptor in mouse brain},
	journal = {Acta Pharmacologica Sinica},
	volume = {1},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Muscarinic cholinergic receptor binding in mouse brain was studied. Binding sites with high affinity and specificity for [3H]QNB were present in P2 fraction of mouse brain homogenate. The ratio of specific/nonspecific binding was 3-6. Muscarinic antagonists and agonists displaced specific [3H]QNB binding, while non-cholinergic drugs had negligible affinity. Displacement potencies of [3H]QNB binding to P2 fraction of mouse brain by a group of glycolate esters, synthesized in our institute, correlated significantly with their central anticholinergic potencies.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/3984}
}