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Two ligands for a GPCR, proton vs lysolipid

  
@article{APS3964,
	author = {Dong-soon Im},
	title = {Two ligands for a GPCR, proton vs lysolipid},
	journal = {Acta Pharmacologica Sinica},
	volume = {26},
	number = {12},
	year = {2016},
	keywords = {},
	abstract = {Recently, two different chemicals have been matched as ligands with the same G-protein-coupled receptor (GPCR). Double-pairing of OGR1 family GPCRs with proton and lysolipid raises several questions. First, whether both are the real ligands for the GPCRs. Second, whether modulation of a GPCR by two chemicals could be possible. Third, one of the chemicals is proton. Proton-sensing not only is a new action mode of GPCR activation, but also it could be generalized in other GPCRs. In this review, I'd like to summarize the issue and discuss questions with pharmacological criteria.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/3964}
}