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PU0213, a novel endothelin receptor antagonist, ameliorates septic renal lesion by suppressing ET system and NF-κB in rats

   
@article{APS3944,
	author = {Hai-bo He and De-zai Dai and Yin Dai},
	title = {PU0213, a novel endothelin receptor antagonist, ameliorates septic renal lesion by suppressing ET system and NF-κB in rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {27},
	number = {9},
	year = {2016},
	keywords = {},
	abstract = {Aim: To examine whether a novel endothelin receptor antagonist, CPU0213, is effective in relieving the acute renal failure (ARF) of septic shock by suppressing the activated endothelin-reactive oxygen species (ET-ROS) pathway and nuclear factor kappa B (NF-κB).
Methods: The cecum was ligated and punctured in rats under anesthesia. CPU0213 (30 mg kg-1 d-1, bid, sc×3 d) was administered 8 h after surgical operation.
Results: In the untreated septic shock group, the mean arterial pressure and survival rate were markedly decreased (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/3944}
}