@article{APS3942,
author = {Jian Qiu and Xiao-hui Wei and Fang Geng and Rui Liu and Jing-wu Zhang and Yu-hong Xu},
title = {Multivesicular liposome formulations for the sustained delivery of interferon alpha-2b},
journal = {Acta Pharmacologica Sinica},
volume = {26},
number = {11},
year = {2016},
keywords = {},
abstract = {Aim: To develop and optimize a sustained release multivesicular liposome (MVL) formulation of interferon (IFN) alpha-2b.
Methods: IFN alpha-2b MVL were prepared using a typical double-emulsion procedure. The sustained release effects of IFN alpha-2b MVL were investigated by monitoring the blood IFN alpha-2b concentration using an enzyme-linked immunosorbent assay test after subcutaneous administration to healthy mice.
Results: IFN alpha-2b was successfully encapsulated in MVL with high efficiency, and the integrity of encapsulated protein was maintained. After subcutaneous injection, the MVL slowly released IFN alpha-2b into systemic circulation in a sustained manner. The estimated serum half-life of IFN alpha-2b was approximately 30 h. In addition, varying the size of the MVL preparations could further modify the in vivo release profile.
Conclusion: IFN alpha-2b MVL may be a useful sustained release formulation in the clinical treatment of viral diseases.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3942}
}