@article{APS3925,
author = {Hua-feng Liu and Dong Liang and Li-ming Wang and Nan Zhou and Cui-wei Yao and Tao Hong and De-shen Tang and Xiao-wen Chen},
title = {Effects of specific interleukin-1bold beta-converting enzyme inhibitor on ischemic acute renal failure in murine models},
journal = {Acta Pharmacologica Sinica},
volume = {26},
number = {11},
year = {2016},
keywords = {},
abstract = {Aim: To study the effect of selective interleukin-1 beta-converting enzyme (ICE, caspase-1) inhibitor on ischemic acute renal failure (ARF).
Methods: Mouse models of ischemic ARF were treated with the specific ICE inhibitor AC-YVAD-CMK. A renal function assay and renal morphological studies were employed to estimate the renal protective effect of AC-YVAD-CMK. The survival rate of mouse models was also analyzed by a time series test. Furthermore, renal ICE activity, mature interleukin-18 (IL-18) protein expression and interferon-alpha (IFN-alpha) mRNA expression were also detected by fluorescent enzyme-linked immunosorbent assay (ELISA), ELISA, and semi-quantitative reverse transcription-polymerase chain reaction, respectively.
Results: The levels of blood urea nitrogen (BUN) and serum creatinine (Scr) increased remarkably in the model controls compared with the sham-operated groups (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3925}
}