@article{APS3894,
author = {Yu Zhou and San-hua Fang and Yi-lu Ye and Li-sheng Chu and Wei-ping Zhang and Meng-ling Wang and Er-qing Wei},
title = {Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats},
journal = {Acta Pharmacologica Sinica},
volume = {27},
number = {9},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the effects of caffeic acid on early and delayed injuries after focal cerebral ischemia in rats, and the possible relation to 5-lipoxygenase inhibition.
Methods: Transient focal cerebral ischemia was induced by middle cerebral artery occlusion in Sprague-Dawley rats. Caffeic acid (10 and 50 mg/kg) was ip injected for 5 d after ischemia. The brain injuries were observed, and the levels of cysteinyl leukotrienes and leukotriene B4 in the brain tissue were measured.
Results: Caffeic acid (50 mg/kg) ameliorated neurological dysfunction and neuron loss, and decreased infarct volume 24 h after ischemia; it attenuated brain atrophy, infarct volume, and particularly astrocyte proliferation 14 d after ischemia. In addition, it reduced the production of leukotrienes (5-lipoxygenase metabolites) in the ischemic hemispheres 3 h and 7 d after ischemia.
Conclusion: Caffeic acid has protective effect on both early and delayed injuries after focal cerebral ischemia in rats; and this effect may partly relate to 5-lipoxygenase inhibition.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3894}
}