@article{APS3822,
author = {Wan-teng Lin and Suh-ching Yang and Kung-tung Chen and Chi-chang Huang and Ning-yuean Lee},
title = {Protective effects of L-arginine on pulmonary oxidative stress and anti-oxidant defenses during exhaustive exercise in rats},
journal = {Acta Pharmacologica Sinica},
volume = {26},
number = {8},
year = {2016},
keywords = {},
abstract = {Aim: To assess the effects of L-arginine (L-Arg) supplementation on pulmonary oxidative stress and antioxidant defenses in rats after exhaustive exercise.
Methods: Rats were randomly divided into four groups: sedentary control (SC), sedentary control with L-Arg treatment (SC+Arg), exhaustive exercise with control diet (E) and exhaustive exercise with L-Arg treatment (E+Arg). Rats in groups SC+Arg and E+Arg received a 2% L-Arg diet. Rats in groups E and E+Arg underwent an exhaustive running test on a motorized treadmill. Pulmonary oxidative stress indices [xanthine oxidase (XO), myeloperoxidase (MPO), and malondialdehyde (MDA)] and antioxidant defense systems [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), and glutathione (GSH)] were investigated in this study.
Results: L-Arg supplementation significantly reduced exercise-induced elevations of XO and MPO activities in lung. L-Arg reversed the exercise-induced increase in SOD and GR activities, but increased CAT and GPX activities. L-Arg administration also significantly increased the GSH levels in plasma.
Conclusion: L-Arg supplementation can prevent elevations of XO and MPO activities in the lung and favorably influence pulmonary antioxidant defense systems after exhaustive exercise.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3822}
}