@article{APS3788,
author = {Yu Tang and Yu-zhi Ge and James Q Yin},
title = {Exploring in vitro roles of siRNA in cardiovascular disease},
journal = {Acta Pharmacologica Sinica},
volume = {28},
number = {1},
year = {2016},
keywords = {},
abstract = {RNA interference (RNAi) is an adaptive defense mechanism through which doublestranded
RNAs silence cognate genes in a sequence-specific manner. It has been
employed widely as a powerful tool in functional genomics studies, target validation
and therapeutic product development. Similarly, the application of smallinterfering
RNA (siRNA) to the silencing of the disease-causing genes involved
in cardiovascular diseases has made great progress. In this overview, we attempt
to provide a brief outline of the current understanding of the mechanism of RNAi
and its potential application to the cardiovascular system, with particular emphasis
on its ability to identify the pathophysiological function of genes related to
several important cardiovascular disorders. The prospects of RNAi-based
therapeutics, as well as the advantages and potential problems, are also discussed.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3788}
}