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Peroxisome proliferator-activated receptor big gamma ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines

   
@article{APS3782,
	author = {Feng-guang Yang and Zhi-wen Zhang and Dian-qi Xin and Chang-jin Shi and Jie-ping Wu and Ying-lu Guo and You-fei Guan},
	title = {Peroxisome proliferator-activated receptor big gamma ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines},
	journal = {Acta Pharmacologica Sinica},
	volume = {26},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Aim: To study the effect of peroxisome proliferator-actived receptor gamma (PPARgamma) ligands on cell proliferation and apoptosis in human renal carcinoma cell lines.
Methods: The expression of PPARgamma was investigated by reverse transcriptase polymerase chain reaction (RT-PCR), Western blot and immunohistochemistry. The effect of thiazolidinedione (TZD) PPARgamma ligands on growth of renal cell carcinoma (RCC) cells was measured by MTT assay and flow cytometric analysis. Cell death ELISA, Hoechst 33342 fluorescent staining and DNA ladder assay were used to observe the effects of PPARgamma ligands on apoptosis. Regulatory proteins of cell cycle and apoptosis were detected by Western blot analysis.
Results: PPARgamma was expressed at much higher levels in renal tumors than in the normal kidney (2.16plusminus0.85 vs 0.90plusminus0.73; P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/3782}
}