TY  - JOUR
AU  - Manov Irena
AU  - Motanis Helen
AU  - Frumin Idan
AU  - Iancu Theodore C
PY  - 2016
TI  - Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects
JF  - Acta Pharmacologica Sinica; Vol 27, No 3 (March 2006): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug-induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N-acetylcysteine or the P-glycoprotein inhibitor verapamil.
UR  - http://www.chinaphar.com/article/view/3743