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Triptolide inhibits NF-κB activation and reduces injury of donor lung induced by ischemia/reperfusion

   
@article{APS3722,
	author = {Jing-kang He and Shu-dong Yu and Hong-Jun Zhu and Jun-chao Wu and Zheng-hong Qin},
	title = {Triptolide inhibits NF-κB activation and reduces injury of donor lung induced by ischemia/reperfusion},
	journal = {Acta Pharmacologica Sinica},
	volume = {28},
	number = {12},
	year = {2016},
	keywords = {},
	abstract = {Aim: To investigate the protective effect of triptolide (TRI) on ischemia/reperfusion-induced injury of transplanted rabbit lungs and to investigate the mechanisms underlying the actions of TRI.
Methods: We established the rabbit lung transplantation model and studied lung injury induced by ischemia/reperfusion and the inhibitory effect of TRI on NF-κB. The severity of lung injury was determined by a gradual decline in PvO2, the degree of lung edema, the increase in the myeloperoxidase (MPO) activity, and the ultrastructural changes of transplanted lungs. The activation of NF-κB was measured by immunohistochemistry. The increase in intercellular adhesion molecule-1 (ICAM-1), which is the target gene of NF-κB, was evaluated by ELISA.
Results: After reperfusion, there was a gradual decline in the PvO2 level in the control group (group I). The level of PvO2 in the group treated with lipopolysaccharide (group II) was significantly decreased, whereas that of the group treated with TRI (group III) was markedly improved (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/3722}
}