@article{APS3720,
author = {Yan Tan and Qiang Tang and Ben-rong Hu and Ji-zhou Xiang},
title = {Antioxidant properties of berberine on cultured rabbit corpus cavernosum smooth muscle cells injured by hydrogen peroxide},
journal = {Acta Pharmacologica Sinica},
volume = {28},
number = {12},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the antioxidant properties of berberine (Ber) on corpus cavenosum smooth muscle cells (CCSMC) in penile erectile dysfunction.
Methods: We examined the effects of Ber on cultured rabbit CCSMC damaged by hydrogen peroxide (H2O2) through examining cell viability by methyl thiazolyl tetrazolium assay and assessing the level of malondialdehyde (MDA), superoxide dismutase (SOD) activity, nitric oxide (NO) products, and lactate dehydrogenase (LDH) release in cells after stimulation with H2O2.
Results: Treatment with 1 mmol/L H2O2 significantly decreased the cell viability, NO products, and SOD activity of CCSMC from 100% to 48.57%±4.1% (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3720}
}