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Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes

   
@article{APS3688,
	author = {Ji-hua Ma and An-tao Luo and Pei-hua Zhang},
	title = {Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes},
	journal = {Acta Pharmacologica Sinica},
	volume = {26},
	number = {7},
	year = {2016},
	keywords = {},
	abstract = {Aim: To study the effect of hydrogen peroxide (H2O2) on persistent sodium current (INa.P) in guinea pig ventricular myocytes.
Methods: The whole-cell, cell-attached, and inside-out patch-clamp techniques were applied on isolated ventricular myocytes from guinea pig. 
Results: H2O2 (0.1 mmol/L, 0.5 mmol/L and 1.0 mmol/L) increased the amplitude of whole-cell INa.P in a concentration-dependent manner, and glutathione (GSH 1 mmol/L) reversed the increased INa.P H2O2 (1 mmol/L) increased persistent sodium channel activity in cell-attached and inside out patches. The mean open probability was increased from control values of 0.015plusminus0.004 and 0.012plusminus0.003 to 0.106plusminus0.011 and 0.136plusminus0.010, respectively (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/3688}
}