@article{APS3634,
author = {Zhen-ping Wang and Shao-xi Cai and Dong-bo Liu and Xiang Xu and Hua-ping Liang},
title = {Anti-inflammatory effects of a novel peptide designed to bind with NF-κB p50 subunit},
journal = {Acta Pharmacologica Sinica},
volume = {27},
number = {11},
year = {2016},
keywords = {},
abstract = {Aim: To explore the anti-inflammatory effects of a novel peptide designed to bind with the NF-κB p50 subunit.
Methods: The affinity of the peptide binding with p50 was measured with a biosensor. Levels of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) from a human acute monocytic leukemia cell line (THP-1) treated with lipopolysaccharide (LPS) were measured using the ELISA method. In vivo anti-inflammatory effects of the peptide were tested with phorbol myristate acetate (PMA)-induced ear edema and zymosan A-induced peritonitis in mice.
Results: The peptide has the ability to interact with the NF-κB p50 subunit and can effectively inhibit TNF-α and IL-6 production in the THP-1 cell line, PMA-induced ear edema and zymosan A-induced peritonitis in mice.
Conclusion: The peptide may have therapeutic potential for the treatment of local acute inflammation.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3634}
}