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Sulfasalazine prevents apoptosis in spermatogenic cells after experimental testicular torsion/detorsion

   
@article{APS3611,
	author = {Yu-gang Zhao and Xin-min Zheng and Ji Zhou and Xiao-li Liu and Xue-min Hu and De-hong Chen and Xue-jun Zhang and Xiao-wei Men and Hong-bo Shi and Zhi-yun Yu},
	title = {Sulfasalazine prevents apoptosis in spermatogenic cells after experimental testicular torsion/detorsion},
	journal = {Acta Pharmacologica Sinica},
	volume = {27},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Aim: To determine whether sulfasalazine can prevent apoptosis in spermatogenic cells by preventing the activation of NF-κB in spermatogenic epithelium in experimental testicular torsion.
Methods: Thirty-two adult male Sprague-Dawley rats were subjected to unilateral 720° testicular torsion for durations of 0 h and 2 h, then the torsion was relieved. The ischemic/reperfused testes were collected for the detection of NF-κB expression with Western blotting and immunohistochemistry techniques, and detection of apoptosis with TUNEL techniques.
Results: The NF-κB coefficient of spermatogenic epithelium and the apoptosis index of spermatogenic cells were significantly different in the operation and the sham-operation groups after experimental testicular torsion (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/3611}
}