@article{APS3604,
author = {Wei Wang and Zhi-jian Yang and Dong-chao Ma and Lian-sheng Wang and Shun-lin Xu and You-rong Zhang and Ke-jiang Cao and Fu-min Zhang and Wen-zhu Ma},
title = {Induction of collateral artery growth and improvement of post-infarct heart function by hepatocyte growth factor gene transfer},
journal = {Acta Pharmacologica Sinica},
volume = {27},
number = {5},
year = {2016},
keywords = {},
abstract = {Aim: To study the effect of adenovirus5-mediated human hepatocyte growth factor (Ad5-HGF) transfer on post-infarct heart failure in a swine model.
Methods: Twelve young Suzhong swine were randomly divided into 2 groups: the Ad5-HGF group (n=6) and the null-Ad5 group (n=6). Four weeks after left anterior descending coronary artery (LAD) ligation, Ad5-HGF was transferred into the myocardium via the right coronary artery. Coronary angiography and gated cardiac perfusion imaging were performed at the end of 4 and 7 weeks after LAD ligation, respectively, to evaluate collateral artery growth and cardiac perfusion. Then all animals were killed, the expression of HGF and α-smooth muscle actin (α-SMA) were evaluated by enzyme-linked immunosorbent assay and immunohistochemistry.
Results: Compared with the null-Ad5 group, higher expression of human HGF was observed in the myocardium in the Ad5-HGF group (109.3±7.8 vs 6.2±2.6, t=30.685, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/3604}
}