TY  - JOUR
AU  - Li Lian
AU  - Zhang Li-ke
AU  - Pang Yong-zheng
AU  - Pan Chun-shui
AU  - Qi Yong-fen
AU  - Chen Li
AU  - Wang Xian
AU  - Tang Chao-shu
AU  - Zhang Jing
PY  - 2016
TI  - Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats
JF  - Acta Pharmacologica Sinica; Vol 27, No 5 (May 2006): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - Aim: To determine the cardioprotective action of ghrelin and des-octanoyl ghrelin in rats with isoproterenol-induced myocardial injury.  Methods: Rats were subcutaneously injected with isoproterenol (ISO; 20, 10, and 5 mg/kg) on d 1, 2 and 3, respectively, and then 3 mg/kg for the next 7 d with or without ghrelin or des-octanoyl-ghrelin (100 mug/kg, twice daily). Plasma ghrelin and growth hormone levels were assayed using radioimmunoassay methods. Growth hormone secretagogue receptor (GHSR) and ghrelin mRNA were determined using RT-PCR. The maximal binding capacity and the affinity for [3H] ghrelin were determined by receptor binding assays.  Results: Compared with controls, ISO-treated rats showed severe myocardial injury, cardiomegaly, infarction-like necrosis and massive fibrosis with increases in irradiated-ghrelin (ir-ghrelin) content in plasma by 67% and myocardia by 66% and in the mRNA level in the myocardia by 93% (P
UR  - http://www.chinaphar.com/article/view/3597